On the cover: In this piece, a flower garden provides a metaphor for the creation and growth of designed protein assemblies. Meador et al. describe machine learning algorithms that greatly expand the ability to generate new types of protein-based molecular cages, whose beauty and diversity are reminiscent of natural flora. 

Image credit: Nika Gladkov.

Publication: A suite of designed protein cages using machine learning algorithms and protein fragment-based protocols.
Meador, K.*, Castells-Graells, R.*, Aguirre, R., Sawaya, M.R., Arbing, M.A., Sherman, T., Senarathne, C., Yeates, T.O.
Structure (2024) doi.org/10.1016/j.str.2024.02.017