On the cover: Tetrahedral nanocage cage component fused to anti-BARD1 DARPin. The structure of an imaging scaffold engineered to bind and study therapeutic protein targets has been determined. Cargo protein-binding DARPins are positioned within the large solvent channels of an unusually porous crystal lattice, suggesting that it may be possible to soak crystals with small target proteins in order to determine their structures.

Publication: X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation.
Agdanowski, M., Castells-Graells, R., Sawaya, M., Cascio, D., Yeates, T.O., Arbing, M.A.
Acta Cryst Section F (2024) doi.org/10.1107/S2053230X2400414X